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点击化学 Alkynyl Palmitic Acid

更新时间:2021-10-15

简要描述:

点击化学 Alkynyl Palmitic Acid:
Alkynyl Palmitic Acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PR

点击化学 Alkynyl Palmitic Acid

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炔基肉豆蔻酸可用于鉴定和表征翻译后的肉豆蔻基化蛋白质 炔基棕榈酸(15-十六烷酸或棕榈酸 (15-yne))是一种修饰的棕榈酸,带有 ω-末端炔烃。 炔基棕榈酸通常用于使用强大的点击化学识别和表征蛋白质的翻译后 S-棕榈酰化。.

Alkynyl myristic acid is can be used to identify and characterize the post-translational myristylated proteins Alkynyl palmitic acid (15-hexadecynoic acid or Palmitic acid (15-yne)) is a modified palmitic acid with an ω-terminal alkyne. Alkynyl palmitic acid often used to identify and characterize the post-translational S-palmitoylation of proteins using the powerful click chemistry (see References).

结构式 :

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参考文献

1. Gray, R. A. V., et al. (2021). Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry. JoVE Journal, 10 (3791), 62107.

2. Li, B., et al. (2020). TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction. Front Cell Dev Biol., 8, 599890.

3. Lee, M.T., et al. (2020). Dietary sphinganine is selectively assimilated by members of themammaliangut microbiome. J Lipid Res .

4. White, F. K. H., et al. (2019). S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane. J Biol Chem., 294 (36), 13487-13501.


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