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Anti-Glutathione抗体D8 (ab19534)

更新时间:2024-03-14

简要描述:

Virogen品牌的Anti-Glutathione抗体[D8] (ab19534):Detection of protein-glutathione addicts on Western blot under non-reducing conditions. ELISA; IP

中文背景介绍:

Glutathione是一种小肽,由三种氨基酸组成,存在于组织中,浓度高达一毫摩尔。它在cysteine的胺基和glutamic acid侧链的羧基之间含有不寻常的肽键。Glutathione参与解毒,它与重金属、溶剂和杀虫剂等毒素结合,并将其转化为可以通过尿液或胆汁排泄的形式。它也是一种重要的抗氧化剂,有助于维持蛋白质的-SH基团的还原形式。慢性功能性Glutathione缺乏症与葡萄糖6-磷酸脱氢酶缺乏症、免疫紊乱、恶性肿瘤发病率增加有关,在HIV疾病的情况下,可能加速了疾病的发病机制。功能性Glutathione缺乏的急性表现可见于用过量APAP。这导致肝细胞中Glutathione的消耗,导致肝衰竭和死亡。


英文背景介绍:

Glutathione is a small peptide composed of three amino acids: cysteine, glutamic acid, and glycine and is present in tissues in concentrations as high as one millimolar. It contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side chain. Glutathione is involved in detoxification, it binds to toxins, such as heavy metals, solvents, and pesticides, and transforms them into a form that can be excreted in urine or bile. It is also an important antioxidant, helping to maintain the -SH groups of proteins in their reduced form. Chronic functional glutathione deficiency is associated with glucose 6-phosphate dehydrogenase deficiency, immune disorders, an increased incidence of malignancies, and in the case of HIV disease, probably accelerated pathogenesis of the disease. Acute manifestations of functional glutathione deficiency can be seen in those who have taken an overdosage of acetaminophen (paracetamol). This results in depletion of glutathione in the hepatocytes, leading to liver failure and death.


Virogen品牌101-A产品名称别名:

Glutathione antibody

GSH antibody

Oxidised glutathione antibody

Reduced glutathione antibody


Anti-Glutathione抗体[D8] (ab19534)实验图片:

image.png

101-A staining Glutathione in cultured murine RAW 264.7 cells by Immunocytochemistry/ Immunofluorescence.
Cells were fixed in paraformaldehyde, permeabilized using 0.1% Triton-X100 in 2% BSA for 15 minutes, blocked with 2% BSA for 1 hour at 22°C and then incubated with 101-A at a 1/150 dilution for 16 hours at 4°C. The secondary used was an Alexa-Fluor 488 conjugated goat anti-mouse IgG (H+L) used at a 1/1000 dilution.


Anti-Glutathione抗体[D8] (ab19534),靶点科技现货,联合Virogen厂家,常年现货,随时发货。原装正品,质量保证。

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