技术文章您现在的位置:首页 > 技术文章 > BroadPharm-什么是阳离子脂质?

BroadPharm-什么是阳离子脂质?

发布时间:2022-08-24   点击次数:175次

What are Cationic Lipids?

Cationic lipids are a class of lipid molecules with a permanent positive charged head group with structure as exemplified by molecule DOTAP (Figure 1). Because of the structure specialty, Cationic lipid are an amphiphilic entity with a head group having hydrophilicity and lipid tails possessing hydrophobicity.


Figure 1: Structure of DOTAP


Application of Cationic Lipid

The first publication about Cationic lipids to transfect DNA into cells was published by Philip Felgner. Currently, Cationic lipids have become one of few major class of molecules in lipid nanoparticle (LNP) drug delivery vehicles, mRNA vaccine encapsulation. Cationic lipids neutralize negative charges and facilitate encapsulation and cell uptake in lipid nanoparticles (LNP). Usually unsaturated, short (<30 monomer) hydrocarbon chains of the lipids are associated with the highest transduction efficiencies. In aqueous environments, these lipids form micelles with positively charged surfaces that complex with DNA. These lipoplexes act to neutralize charge repulsion between the cell membrane and DNA and promote endocytosis, similar to the mechanism of cationic polymers.

Lipid supplier and customer synthesis

As a leading biochemical supplier worldwide, BroadPharm offer a wide array of Lipid molecules, such as Ionizable lipids, cationic lipids, helper lipids, and PEG lipids to our clients worldwide. BroadPharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research.


参考文献Journal Reference:

1. S. Simoes, A. Filipe, (March 2, 2005). "Cationic liposomes for gene delivery". Expert Opinion on Drug Delivery. 2 (2): 237-254.

2. X. Hou, T. Zaks, R. Langer, Y. Dong, "Nature Review Materials", (2021)

3.B. Pitard, D. Habrant , Supramolecular Medicinal Chemistry and Chemical Biology, in Comprehensive Supramolecular Chemistry II, 2017


靶点科技(北京)有限公司

靶点科技(北京)有限公司

地址:中关村生命科学园北清创意园2-4楼2层

© 2022 版权所有:靶点科技(北京)有限公司  备案号:京ICP备18027329号-2  总访问量:99679  站点地图  技术支持:化工仪器网  管理登陆

QQ在线客服
联系方式

15210359867

4000043669