kerafast代理Anti-VSV-M [23H12] 抗体

kerafast总代理靶点科技货号EB0011单克隆抗体Anti-VSV-M [23H12] Antibody与VSV-M蛋白反应。

产品特色：

-与VSV-M蛋白发生反应

-适用于蛋白质印迹应用

背景介绍：

水疱性口炎病毒（VSV）是一种经过充分研究的包膜负链RNA病毒。VSV 基因组编码 5 种蛋白质：N、P、M、G 和 L。G蛋白（糖蛋白）位于病毒粒子表面，负责病毒附着和渗透。此外，许多慢静脉载体是用来自印第安纳州血清型的VSV-G假分型的。

水疱性口炎病毒（VSV）是一种经过充分研究的包膜负链RNA病毒。VSV 基因组编码 5 种蛋白质：N、P、M、G 和 L。M蛋白（或基质蛋白）负责结合核衣壳并将其凝聚成紧密盘绕的螺旋，并将核衣壳与包膜结合。M蛋白的这种活性使病毒具有弹状的形状。除了M蛋白在病毒组装中的作用外，它还负责介导VSV发病机制的分子机制。野生M型蛋白抑制感染细胞中的宿主基因表达并抑制抗病毒反应。

Background：

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.

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