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ClickChemistryTools点击化学铜配体THPTA

发布时间:2022-12-24   点击次数:336次

中文介绍:

THPTA(三羟丙基三唑基甲胺)是一种水溶性、非常有效的加速配体,用于铜催化的炔烃-叠氮化物点击化学反应(CuAAC)。除了大大提高CuAAC的速率外,THPTA还最大限度地减少了对所探测细胞或生物体生理状态的扰动,并通过进一步降低催化剂配方中的Cu负载量,允许有效的生物偶联与抑制细胞细胞毒性。水溶性THPTA配体允许整个反应在水中运行,进一步简化了点击化学。


英文介绍:

THPTA (tris-hydroxypropyltriazolylmethylamine) is a water-soluble, very effective accelerating ligand for copper-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). In addition to greatly enhancing the rate of CuAAC, THPTA minimizes perturbations to the physiological state of the cells or organisms probed and allows for the effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation. The water-soluble THPTA ligand further simplifies click chemistry by allowing the entire reaction to be run in water.


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参考文献:

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