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Emfret公司血小板消除抗体R300说明书

更新时间:2024-01-23   点击次数:167次

Emfret公司血小板消除抗体R300说明书

Antibodies for Platelet Depletion in Mice

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# R300




产品资料


货号

R300

同种型(isotype)

大鼠IgG (Wistar)

含量

0.5 mg purified immunoglobulins in PBS, sterile filtered

包装

1ML

浓度

0.5 mg/ml

本产品只用于科研,不用于诊断,也不属于医疗用品

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特异性: This antibody preparation contains a mixture of purified rat monoclonal antibodies  directed

against mouse GPIba (CD42b). Targeting of this receptor with divalent IgGs results in profound and

irreversible Fc-independent plaet depletion in mice1,2. Plaet depletion is frequently used to study

the general role of plaets in (patho-) physiology3.


制备 : 抗体是杂交瘤细胞上清通过G-Sepharose纯化所得,内毒素含量小于 0.0025 EU/µg


保存和运输:4度保存和运输,保质期为6个月 ,无菌保存不含防腐剂,分装保存-20度至少可以保存一年以上,但请避免反复冻融


使用方法: 按动物体重注射抗体,用 量为2 µg抗体/g动物体重,可以参见上图。如果4 µg抗体/g动物体重,可以持续更长时间。注射后60分钟内可以去除血小板95%以上,建议每次注射100-200µL抗体(用无菌PBS稀释)。详情联系靶点科技技术支持。可以联合清除巨噬细胞(LIPOSOMA,CP-005-005)和中性粒细胞,咨询综合解决方案。




引用文献:

1. Bergmeier W, Rackebrandt K, Schroder W, Zirngibl H, Nieswandt B. (2000) Structural and functional characterization of the mouse von Willebrand

factor receptor GPIb-IX with novel monoclonal antibodies. Blood. 95:886-93.

2. Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, and Zirngibl H. (2000) Identification of critical antigen-specific mechanisms in the

development of immune thrombocytopenic purpura in mice. Blood. 96:2520-27.

3. Elzey BD, Tian J, Jensen RJ et al. (2003) Plaet-mediated modulation of adaptive immunity. A communication link between innate and adaptive

immune compartments. Immunity.19:9-19.



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