The unnatural azido-containing monosaccharide building block. The azide moiety can be used for modification though chemoselective ligation chemistries including CuAAC, Cu-free click reaction or Staudinger ligation. The acetyl groups increase solubility in many solvents and make handling of this reagent easier. Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis. PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Ac4GalNAz 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 分子的合成。
靶点科技现货N-azidoacetylgalactosamine-tetraacylated (Ac4GalNAz) (CCT-1086)
精选文献Selected References
1.Simon P. Wisnovsky, et al. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS, 117 (41), 25293-25301.
2.Ranzinger, R., et al. (2020). Mass Spectrometric Method for the Unambiguous Profiling of Cellular Dynamic Glycosylation. ACS Chem. Biol., 15, 10, 2692-2701.
3.Suttapitugsakul, S., et al. (2019). Surface Glycoproteomic Analysis Reveals That Both Unique and Differential Expression of Surface Glycoproteins Determine the Cell Type. Anal. Chem., 91(10), 6934–42.
| 生物活性 | Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | |||
|---|---|---|---|---|
| IC50 & Target |
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| 体外研究 (In Vitro) | PROTAC 包含两个不同的配体，通过一个接头连接；一个是 E3 泛素连接酶的配体，另一个是靶蛋白的配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. | |||
| 分子量 | 430.37 | |||
| Formula | C16H22N4O10 | |||
| CAS 号 | 653600-56-7 | |||
| 性状 | 固体 | |||
| 颜色 | White to off-white | |||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||
| 储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
