技术文章您现在的位置:首页 > 技术文章 > Clickchemistrytools/Vectorlabs现货Ac4ManNAz货号1086-25

Clickchemistrytools/Vectorlabs现货Ac4ManNAz货号1086-25

更新时间:2024-03-13   点击次数:119次

The unnatural azido-containing monosaccharide building block. The azide moiety can be used for modification though chemoselective ligation chemistries including CuAAC, Cu-free click reaction or Staudinger ligation. The acetyl groups increase solubility in many solvents and make handling of this reagent easier. Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis. PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Ac4GalNAz 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。


靶点科技现货N-azidoacetylgalactosamine-tetraacylated (Ac4GalNAz) (CCT-1086)

精选文献Selected References

1.Simon P. Wisnovsky, et al. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS, 117 (41), 25293-25301.

2.Ranzinger, R., et al. (2020). Mass Spectrometric Method for the Unambiguous Profiling of Cellular Dynamic Glycosylation. ACS Chem. Biol., 15, 10, 2692-2701.

3.Suttapitugsakul, S., et al. (2019). Surface Glycoproteomic Analysis Reveals That Both Unique and Differential Expression of Surface Glycoproteins Determine the Cell Type. Anal. Chem., 91(10), 6934–42.



生物活性

Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target


Alkyl-Chain

体外研究
(In Vitro)

PROTAC 包含两个不同的配体,通过一个接头连接;一个是 E3 泛素连接酶的配体,另一个是靶蛋白的配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

430.37

Formula

C16H22N4O10

CAS 号

653600-56-7

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)





靶点科技(北京)有限公司

靶点科技(北京)有限公司

地址:中关村生命科学园北清创意园2-4楼2层

© 2024 版权所有:靶点科技(北京)有限公司  备案号:京ICP备18027329号-2  总访问量:214241  站点地图  技术支持:化工仪器网  管理登陆