Ub-VS：a potent and specific inhibitor of deubiquitinating enzymes (DUBs)。一种有效的特异性去泛素化酶 （DUB） 抑制剂。
code: UbiQ-108
category: activity-based probes
applications:
crystallization, purification, western blot, phenotypic protein profiling, dub activity profiling
英文描述：
Ubiquitin-Viny Sulfone (UbiQ-108) is a potent and specific inhibitor of deubiquitinating enzymes (DUBs). This activity probe can be used for activity profiling experiments and determining DUB inhibitor specificity. It targets all two of the major DUB families: USP and OTU.
中文描述：
Ubiquitin-Viny Sulfone （UbiQ-108） 是一种有效的特异性去泛素化酶 （DUB） 抑制剂。该活性探针可用于活性分析实验和确定 DUB 抑制剂特异性。它针对所有两个主要的 DUB 系列：USP 和 OTU。
产品文献：
1.Galardy, P., et al. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification. Methods in Enzymology. 399, 120-131 (2005).
ncbi.nlm.nih.gov/pubmed/16338352
2. de Jong, A., et al. Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes. ChemBiochem 13, 2251-2258 (2012).
ncbi.nlm.nih.gov/pubmed/23011887
3. Wrigley, J.D. et al. Enzymatic characterisation of USP7 deubiquitinating activity and inhibition. Cell Biochem. Biophys. 60, 99-111 (2011)
ncbi.nlm.nih.gov/pubmed/21468692
