小鼠急性损伤模型，比较常见的是LPS诱导的急性腹膜炎小鼠模型；ConA 诱导的肝炎模型和盲肠结扎穿刺（CLP）诱导的败血症小鼠模型。如何在急性模型中清除巨噬细胞，可以参考如下这篇文献。
论文信息：
论文题目：Glycogen metabolism regulates macrophage-mediated acute inflammatory responses
期刊名称：Nature Communications
时间期卷：11, Article number: 1769(2020)
在线时间：2020年4月14日
DOI： doi.org/10.1038/s41467-020-15636-8
产品信息：
货号：C-005
规格：5ml
品牌：Liposoma
产地：荷兰
名称：Clodronate Liposomes
办事处：Target Technology(靶点科技)
Clodronate Liposomes氯膦酸盐脂质体清除巨噬细胞介导的急性炎症模型 ，荷兰Liposoma巨噬细胞清除剂ClodronateLiposomes见刊于Nature Communications：糖原代谢调节巨噬细胞介导的急性炎症反应。
氯膦酸二钠脂质体ClodronateLiposomes清除三种急性损伤模型巨噬细胞解决方案：
In the LPS-induced acute peritonitis mouse model, C57BL/6J mice were treated with GPI (10 μg g−1, i.p., 12 and 4 h before LPS injection), 6AN (15 μg g−1, i.p., 12 and 4 h before LPS injection) or clodronate liposomes (Clod, 10 μL g−1, i.p., 36 and 4 h before- and 36 h after- LPS injection), followed by i.p. injection of 20 μg g−1 body weight LPS. In the ConA-induced hepatitis model, C57BL/6J mice were treated with GPI (10 μg g−1, i.v., 12 and 4 h before ConA injection), 6AN (15 μg g−1, i.v., 12 and 4 h before ConA injection) or clodronate liposomes (Clod, 10 μL g−1, i.p., 36 and 4 h before- and 36 h after- ConA injection), followed by i.v. injection of 15 μg g−1 body weight ConA. In the cecal ligation and puncture (CLP)-induced sepsis mouse model, C57BL/6J mice were treated with GPI (10 μg g−1, i.p., 12 and 4 h before CLP procedure), 6AN (15 μg g−1, i.p., 12 and 4 h before CLP procedure) or clodronate liposomes (10 μL g−1, i.p., 36 and 4 h before- and 36 h after- CLP procedure), followed by CLP procedure.
