德国EMFRET公司专注心血管和血液系统研究用抗体研发和生产，供应的抗体包括清除血液中血小板、流式细胞术鉴定分析小鼠血小板表面糖蛋白，EMFRET公司的抗体不仅适用于流失分析、WB检测，还可用于免疫组化/免疫荧光及免疫共沉淀检。现货订购，联系靶点科技。
重点产品：R300 Antibodies for Platelet Depletion in Mice
Product Information
Catalog Number: R300
Isotype: Rat IgG (Wistar)
Contents: 0.5 mg purified immunoglobulins in PBS, sterile filtered
Concentration: 0.5 mg/ml For research use only, not for diagnost
仅供研究使用，不可用于诊断或治疗。本产品不属于医疗器械。
特异性：本抗体制剂含有针对小鼠GPIbα(CD42b)的纯化大鼠单克隆抗体混合物。二价IgG靶向该受体，可导致小鼠出现严重且不可逆的Fc非依赖性血小板耗竭1,2。血小板耗竭常用于研究血小板在（病理）生理学中的一般作用3。
制备与储存：抗体由杂交瘤细胞培养上清液经 Protein G-Sepharose 层析纯化而成，蛋白内毒素含量低于 0.00025 ng/µg (< 0.0025 EU/µg)。4°C 保存，自发货之日起可稳定保存六个月。请保持无菌，本制剂不含防腐剂。分装后可在 -20°C 保存至少一年。避免反复冻融。
使用方法：本制剂经优化，静脉注射2 µg/g体重后，60分钟内血小板计数可减少95%以上。建议注射100-200 µl（用无菌PBS稀释）的抗体。
文献参考：
1. Bergmeier W, Rackebrandt K, Schroder W, Zirngibl H, Nieswandt B. (2000) Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies. Blood. 95:886-93. 2. Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, and Zirngibl H. (2000) Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. Blood. 96:2520-27. 3. Elzey BD, Tian J, Jensen RJ et al. (2003) Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity.19:9-19.
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