细胞衰老是细胞停止分裂的现象。衰老可由内部（氧化应激、DNA损伤等）和外部（毒素、紫外线等）因素诱导。衰老是一种生长停滞的状态，细胞在这种状态下保持活力但停止分裂。衰老细胞表现出细胞大小增加，β-半乳糖苷酶、p53和P16活性的衰老相关表达，以及基因表达模式的改变。
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SenTraGor™ (GL13) is an innovative reagent for the detection of senescence. Senescent cells play a potent role in normal development, tissue homeostasis, aging and a wide spectrum of age related disorders. Up to now, a major problem in the field of senescence was the absence of a reliable marker to specifically detect these cells, especially in situ. SenTraGor™ (GL13) is a biotinylated Sudan Black B based chemical reagent that was designed to overcome this constraint.
SenTraGor™ (GL13) staining allows the detection of senescence in any biological material. Direct visualization of senescent cells can be achieved in all archival tissue specimens (formalin-fixed paraffin-embedded) and cells from biopsies or cell cultures.
