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Emfret血小板清除原理CD42b背景知识介绍

更新时间:2024-05-27   点击次数:150次

Emfret血小板清除原理CD42b背景知识,靶标CD42b:

This antibody preparation contains a mixture of purified rat monoclonal antibodiesdirected against mouse GPIbα(CD42b). Targeting of this receptor with divalent IgGs results in profound and irreversible Fc-independent platelet depletion in mice. Platelet depletion is frequently used to study the general role of platelets in (patho-) physiology.


CD42b英文背景知识介绍:

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.


CD42b中文背景知识介绍:

CD42b 是一种血小板活化标志物,作为聚集因子参与凝血过程。它与细胞外基质以及粘附分子相互作用。CD42b 的表达和激活似乎受 VEGF 和 PDGF 的调控。CD42b 与 GPIb β、GPIX 和 GPV 一起组成 GPIb-IX-V 受体复合物,通过将血小板拴在血栓形成表面,在富血小板血栓形成过程中至关重要。CD42b 与暴露在血管损伤部位的血管性血友病因子 (VWF) 以及凝血酶、凝血因子 XI 和 XII、高分子激肽原、TSP-1、整合素 Mac-1 和 P-选择素结合。CD42b 的细胞外结构域通过其相互作用也有助于转移。此外,CD42b抗原在血小板和骨髓中的巨核细胞上表达。CD42b 中描述了几种多态性和突变,其中一些是 Bernard-Soulier 综合征和血小板型血管性血友病的原因。


R300抗体Antibodies for Platelet Depletion in Mice 实物图片:

Emfret血小板清除原理CD42b背景知识介绍


R300抗体靶点CD42b生物信息学背景知识:

蛋白别名: Antigen CD42b-alpha; CD42b; glycoprotein Ib (platelet), alpha polypeptide; GP-Ib alpha; GPIB; GPIb alpha; GPIX; MGC34595; 

mutant platelet membrane glycoprotein Ib-alpha; Platelet glycoprotein Ib alpha chain; Platelet GPIX; platelet membrane 

glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha


基因别名: BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GP1BA; GPIbA; GPIbalpha; VWDP



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