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Click Chemistry Tools产品Alkynyl Palmitic Acid说明书

更新时间:2024-06-28   点击次数:175次

Alkynyl myristic acid is can be used to identify and characterize the post-translational myristylated proteins Alkynyl palmitic acid (15-hexadecynoic acid or Palmitic acid (15-yne)) is a modified palmitic acid with an ω-terminal alkyne. Alkynyl palmitic acid often used to identify and characterize the post-translational S-palmitoylation of proteins using the powerful click chemistry。

炔基肉豆蔻酸可用于鉴定和表征翻译后肉豆蔻酸的炔基棕榈酸(15-十六烷酸或棕榈酸(15-炔))是一种具有ω末端炔烃的改性棕榈酸。炔基棕榈酸常用于使用强大的点击化学来鉴定和表征蛋白质的翻译后S-棕榈酰化。

Alkynyl Palmitic Acid (Alk-C16) 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。Alkynyl Palmitic Acid 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

Click Chemistry Tools产品Alkynyl Palmitic Acid说明书

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。


Selected References参考文献

1. Gray, R. A. V., et al. (2021). Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry. JoVE Journal, 10 (3791), 62107.

2. Li, B., et al. (2020). TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction. Front Cell Dev Biol., 8, 599890.

3. Lee, M.T., et al. (2020). Dietary sphinganine is selectively assimilated by members of themammaliangut microbiome. J Lipid Res .

4. White, F. K. H., et al. (2019). S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane. J Biol Chem., 294 (36), 13487-13501.


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