中文摘要：
妊娠会引发机体免疫系统发生深刻变化。然而，妊娠状态下呼吸道针对流感感染的免疫适应性变化，及其对疾病严重程度的影响，目前仍尚不明确。
本研究利用妊娠中期临床前动物模型，揭示了一种鼻腔局部宿主抗甲型流感病毒（IAV）防御增强的分子机制：该机制可抑制病毒复制，并减弱肺内免疫应答反应强度。因此，妊娠小鼠在感染甲型流感病毒后，肺部病理损伤减轻，气道功能得以维持。
这种对病毒复制的早期抑制不依赖 I 型干扰素（IFN），而是由鼻腔内白介素 - 17 阳性（IL-17⁺）γδ T 细胞驱动 抗菌肽（AMPs） 表达上调所介导。妊娠期上呼吸道这套抵御甲型流感病毒感染的宿主防御通路，能够限制病毒早期侵染、阻止病毒向肺部扩散，进而维持母体健康状态。
英文摘要：
Pregnancy is associated with profound changes in immunity. However, pregnancy-related respiratory immune adaptations in response to influenza infection and their impact on disease severity remain unclear. Here, we describe, in a preclinical model of mid-gestation pregnancy, a mechanism of enhanced host defense against influenza A virus (IAV) localized to the nasal cavity that limits viral replication and reduces the magnitude of intrapulmonary immune responses. Consequently, the pregnant mice show reduced pulmonary pathology and preserved airway function after IAV infection. The early restriction of viral replication is independent of type I interferon (IFN) but dependent on increased antimicrobial peptides (AMPs) driven by interleukin-17+ (IL-17+) γδ+ T cells within the nasal passages. This pathway of host defense against IAV infection in the upper airways during pregnancy restricts early viral infection and prevents virus dissemination into the lung supporting maternal fitness.
论文信息：
论文题目：Pregnancy enhances antiviral immunity independent of type I IFN but dependent on IL-17–producing γδ+ T cells in the nasal mucosa
期刊名称：Science Advances
时间期卷：Vol 10, Issue 39(2024)
在线时间：2024年9月27日
DOI: 10.1126/sciadv.ado7087
产品信息：
货号：CP-005-005
规格：5ml+5ml
品牌：Liposoma
产地：荷兰
名称：Clodronate Liposomes&Control Liposomes
办事处：靶点科技
Clodronate Liposomes氯膦酸盐脂质体在甲型流感病毒感染妊娠小鼠模型种清除肺部巨噬细胞。荷兰Liposoma巨噬细胞清除剂ClodronateLiposomes见刊于Science Advances：妊娠可增强抗病毒免疫，该过程不依赖 I 型干扰素，而依赖鼻黏膜中分泌 IL-17 的 γδ⁺ T 细胞
Liposoma巨噬细胞清除剂Clodronate Liposomes氯膦酸二钠脂质体清除巨噬细胞的材料和方法：
巨噬细胞清除材料和方法文献截图：
